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Erg251 has complex and pleiotropic effects on azole susceptibility, filamentation, and stress response phenotypes

2024-03-06

Abstract excerpt

<h4>ABSTRACT</h4> Ergosterol is essential for fungal cell membrane integrity and growth, and numerous antifungal drugs target ergosterol. Inactivation or modification of ergosterol biosynthetic genes can lead to changes in antifungal drug susceptibility, filamentation and stress response. Here, we found that the ergosterol biosynthesis gene ERG251 is a hotspot for point mutations during adaptation to antifungal...

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Literature Corpus work
98ca38aa-a7a1-569c-abc5-74a13fbc5f7e
DOI
10.1101/2024.03.06.583770
Open publication

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Erg251 has complex and pleiotropic effects on azole susceptibility, filamentation, and stress response phenotypesDOI 10.1101/2024.03.06.583770
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