Article
A gain-of-function mutation in the transcription factor Upc2p causes upregulation of ergosterol biosynthesis genes and increased fluconazole resistance in a clinical Candida albicans isolate.
Eukaryotic cell - 1 Jul 2008
Dunkel Nico, Liu Teresa T, Barker Katherine S, Homayouni Ramin, Morschhäuser Joachim, Rogers P David
Abstract excerpt
In the pathogenic yeast Candida albicans, the zinc cluster transcription factor Upc2p has been shown to regulate the expression of ERG11 and other genes involved in ergosterol biosynthesis upon exposure to azole antifungals. ERG11 encodes lanosterol demethylase, the target enzyme of this antifungal class. Overexpression of UPC2 reduces azole susceptibility, whereas its disruption results in hypersusceptibility to...
Topics
Join the communities discussing this publication.