Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TOP2 gene is involved in the pathogenicity of Candida albicans.

Molecular and cellular biochemistry - 1 May 2012

Zheng Hao, Yu Yong-Sheng

Abstract excerpt

Candida albicans is a common cause of morbidity in hospitalized and immunosuppressed patients. There are still many unknown genes involved in the virulence of C. albicans. The present study aims to examine the effect of TOP2 gene in candidal virulence, including hyphal growth, phospholipase and proteinase activity. Targeted gene disruption of both TOP2 alleles in a wild-type strain of C. albicans produced hyphae...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aspartic Acid Endopeptidases
Share to Candida albicans
Share to DNA Topoisomerases, Type II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Fungal

Share to Hyphae

Share to Mice, Inbred BALB C

Share to Peptide Hydrolases

Share to Phospholipases

Source

Identifiers

PMID: 22203422
DOI: 10.1007/s11010-011-1203-9

Genes

PLB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TOP2 gene is involved in the pathogenicity of Candida albicans.PMID 22203422Read ↗

Investigation of Candida parapsilosis virulence regulatory factors during host-pathogen interaction.Semantic proximity Read ↗

Virulence Factors and Azole-Resistant Mechanism of Candida Tropicalis Isolated From CandidemiaSemantic proximity Read ↗

Characterization of Virulence Factors in Candida Species Causing Candidemia in a Tertiary Care Hospital in Bangkok, ThailandSemantic proximity Read ↗

Investigating the presence of phospholipase and secreted aspartyle proteinase gene family in different genotypes of Candida albicans species.Semantic proximity Read ↗

UPC2 mutations and development of azole resistance in Candida albicans hospital isolates from Lebanon.Semantic proximity Read ↗

TOP2 gene disruption reduces drug susceptibility by increasing intracellular ergosterol biosynthesis in Candida albicans.Semantic proximity Read ↗

Inhibitory Effect of Morin Against Candida albicans Pathogenicity and Virulence Factor Production: An in vitro and in vivo ApproachesSemantic proximity Read ↗

Tandem Mass Spectrometric Cell Wall Proteome Profiling of a Candida albicans hwp2 Mutant Strain.Semantic proximity Read ↗

A Versatile Overexpression Strategy in the Pathogenic Yeast Candida albicans: Identification of Regulators of Morphogenesis and FitnessSemantic proximity Read ↗

Sequence Variation of Candida albicans Sap2 Enhances Fungal Pathogenicity via Complement Evasion and Macrophage M2-Like Phenotype Induction.Semantic proximity Read ↗

Inactivation of the phospholipase B gene PLB5 in wild-type Candida albicans reduces cell-associated phospholipase A2 activity and attenuates virulence.Semantic proximity Read ↗

The phosphatome of opportunistic pathogen Candida speciesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.