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Article

The Candida glabrata Upc2A transcription factor is a global regulator of antifungal drug resistance pathways.

PLoS genetics - 1 Sept 2021

Vu Bao Gia, Stamnes Mark A, Li Yu, Rogers P David, Moye-Rowley W Scott

Abstract excerpt

The most commonly used antifungal drugs are the azole compounds, which interfere with biosynthesis of the fungal-specific sterol: ergosterol. The pathogenic yeast Candida glabrata commonly acquires resistance to azole drugs like fluconazole via mutations in a gene encoding a transcription factor called PDR1. These PDR1 mutations lead to overproduction of drug transporter proteins like the ATP-binding cassette...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34591857
DOI: 10.1371/journal.pgen.1009582
PMCID: PMC8509923

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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