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Disruption of the <em>UPC2</em> Gene Enhances Fluconazole Antifungal Activity by Inhibiting <em>HAC1</em> mRNA Splicing in <em>Candida albicans</em>

2026-03-18

Abstract excerpt

Azole resistance in Candida albicans is an increasing clinical challenge. Upc2 is a key transcription factor regulating ergosterol biosynthesis, but its additional roles in azole tolerance remain unclear. This study investigated whether Upc2 contributes to azole resistance through pathways beyond ergosterol synthesis. Chemical sensitivity screening, RNA sequencing, flow cytometry, and molecular assays were perform...

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Literature Corpus work
ffeaab05-fcfc-560b-8623-81c79c90a782
DOI
10.20944/preprints202603.1460.v1
Open publication

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Disruption of the <em>UPC2</em> Gene Enhances Fluconazole Antifungal Activity by Inhibiting <em>HAC1</em> mRNA Splicing in <em>Candida albicans</em>DOI 10.20944/preprints202603.1460.v1
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