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Article

Candida albicans zinc cluster protein Upc2p confers resistance to antifungal drugs and is an activator of ergosterol biosynthetic genes.

Antimicrobial agents and chemotherapy - 1 May 2005

MacPherson Sarah, Akache Bassel, Weber Sandra, De Deken Xavier, Raymond Martine, Turcotte Bernard

Abstract excerpt

The human pathogen Candida albicans is responsible for a large proportion of infections in immunocompromised individuals, and the emergence of drug-resistant strains is of medical concern. Resistance to antifungal azole compounds is often due to an increase in drug efflux or an alteration of the pathway for synthesis of ergosterol, an important plasma membrane component in fungi. However, little is known about...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15855491
DOI: 10.1128/AAC.49.5.1745-1752.2005
PMCID: PMC1087678

Genes

ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Candida albicans zinc cluster protein Upc2p confers resistance to antifungal drugs and is an activator of ergosterol biosynthetic genes.PMID 15855491Read ↗

Role of Candida albicans transcription factor Upc2p in drug resistance and sterol metabolism.Semantic proximity Read ↗

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Azole resistance is mediated by integration of sterol gene regulation and membrane transporter production by the zinc cluster-containing transcription factor Upc2A in <i>Candida glabrata</i>Semantic proximity Read ↗

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Candida glabrata maintains two HAP1 ohnologs, HAP1A and HAP1B , for distinct roles in ergosterol gene regulation to mediate sterol homeostasis under azole and hypoxic conditionsSemantic proximity Read ↗

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