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Article

Squalene epoxidase encoded by ERG1 affects morphogenesis and drug susceptibilities of Candida albicans.

The Journal of antimicrobial chemotherapy - 1 Jun 2005

Pasrija Ritu, Krishnamurthy Shankarling, Prasad Tulika, Ernst Joachim F, Prasad Rajendra

Abstract excerpt

OBJECTIVES: Functional characterization of the erg1 mutant of ergosterol biosynthesis of Candida albicans. METHODS: We disrupted the ERG1 gene of C. albicans, which encodes squalene epoxidase (EC 1.14.99.7). Since the disruption of both alleles of ERG1 was lethal, the second allele of a heterozygous disruptant was placed under the control of a regulable promoter, MET3p, which is repressed by methionine and...

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Identifiers

PMID: 15845783
DOI: 10.1093/jac/dki112

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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