Article
Genetic variants and disease-associated factors contribute to enhanced interferon regulatory factor 5 expression in blood cells of patients with systemic lupus erythematosus.
Arthritis and rheumatism - 1 Feb 2010
Feng Di, Stone Rivka C, Eloranta Maija-Leena, Sangster-Guity Niquiche, Nordmark Gunnel, Sigurdsson Snaevar, Wang Chuan, Alm Gunnar, Syvänen Ann-Christine, Rönnblom Lars, Barnes Betsy J
Abstract excerpt
OBJECTIVE: Genetic variants of the interferon (IFN) regulatory factor 5 gene (IRF5) are associated with susceptibility to systemic lupus erythematosus (SLE). The contribution of these variants to IRF-5 expression in primary blood cells of SLE patients has not been addressed, nor has the role of type I IFNs. The aim of this study was to determine the association between increased IRF-5 expression and the IRF5 risk...
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