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Article

Variants in the interferon regulatory factor 5 gene confer genetic risk for systemic lupus erythematosus in a Han Chinese population.

Annals of medicine - 1 Dec 2026

Xu Wenqi, Liu Jiayao, Yu Peilin, Shi Xiaofei, Liu Rongzeng

Abstract excerpt

BACKGROUND: Interferon regulatory factor 5 (IRF5), integral to interferon signaling pathways, has been identified as a susceptibility locus for systemic lupus erythematosus (SLE). Nevertheless, the relationship between IRF5 variants and SLE risk within the Han Chinese demographic remains inadequately characterized. MATERIALS AND METHODS: Genotyping of two functional single nucleotide variants (SNVs) in IRF5 was...

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PMID: 41614394
DOI: 10.1080/07853890.2026.2622737
PMCID: PMC12862840

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