Structural insertion/deletion variation in IRF5 is associated with a risk haplotype and defines the precise IRF5 isoforms expressed in systemic lupus erythematosus.

doi:10.1002/art.22497

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Article

Structural insertion/deletion variation in IRF5 is associated with a risk haplotype and defines the precise IRF5 isoforms expressed in systemic lupus erythematosus.

Arthritis and rheumatism - 1 Apr 2007

Kozyrev Sergey V, Lewén Susanna, Reddy Prasad M V Linga, Pons-Estel Bernardo, Witte Torsten, Junker Peter, Laustrup Helle, Gutiérrez Carmen, Suárez Ana, Francisca González-Escribano Maria, Martín Javier, Alarcón-Riquelme Marta E

Abstract excerpt

OBJECTIVE: To determine whether specific isoforms of IRF5 are transcribed in patients with systemic lupus erythematosus (SLE) who have risk genotypes in the exon 1B donor splice site at single-nucleotide polymorphism (SNP) no. rs2004640. METHODS: Peripheral blood mononuclear cells were obtained from SLE patients and healthy controls from Argentina, Spain, and Germany and from trio families from Spain and Denmark....

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PMID: 17393452
DOI: 10.1002/art.22497

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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