Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RNA-Seq for enrichment and analysis of IRF5 transcript expression in SLE.

PloS one - 1 Jan 2013

Stone Rivka C, Du Peicheng, Feng Di, Dhawan Kopal, Rönnblom Lars, Eloranta Maija-Leena, Donnelly Robert, Barnes Betsy J

Abstract excerpt

Polymorphisms in the interferon regulatory factor 5 (IRF5) gene have been consistently replicated and shown to confer risk for or protection from the development of systemic lupus erythematosus (SLE). IRF5 expression is significantly upregulated in SLE patients and upregulation associates with IRF5-SLE risk haplotypes. IRF5 alternative splicing has also been shown to be elevated in SLE patients. Given that human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Monocytes
Share to Alternative Splicing
Share to Gene Expression Profiling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to High-Throughput Nucleotide Sequencing

Share to Interferon Regulatory Factors

Share to Lupus Erythematosus, Systemic

Source

Open in PubMed Open full text

Identifiers

PMID: 23349905
DOI: 10.1371/journal.pone.0054487
PMCID: PMC3548774

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RNA-Seq for enrichment and analysis of IRF5 transcript expression in SLE.PMID 23349905Read ↗

Genetic variants and disease-associated factors contribute to enhanced interferon regulatory factor 5 expression in blood cells of patients with systemic lupus erythematosus.Semantic proximity Read ↗

Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus.Semantic proximity Read ↗

A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus.Semantic proximity Read ↗

A Comprehensive Analysis of Type I Interferon Risk Gene Signatures in Systemic Lupus Erythematosus.Semantic proximity Read ↗

Effects of IRF5 lupus risk haplotype on pathways predicted to influence B cell functions.Semantic proximity Read ↗

Integrative Functional Genomics Identifies Systemic Lupus Erythematosus Causal Genetic Variant in the IRF5 Risk Locus.Semantic proximity Read ↗

Genome-Wide Identification of Cell Type-Specific Susceptibility Genes for SLE Through the Analysis of RNA Modification-Associated SNPs.Semantic proximity Read ↗

Transcriptomic studies unravel the molecular and cellular complexity of systemic lupus erythematosus: A reviewSemantic proximity Read ↗

IRF5 genetic risk variants drive myeloid-specific IRF5 hyperactivation and presymptomatic SLE.Semantic proximity Read ↗

Identification of LncRNA Linc00513 Containing Lupus-Associated Genetic Variants as a Novel Regulator of Interferon Signaling PathwaySemantic proximity Read ↗

Single-cell RNA-seq reveals cell type–specific molecular and genetic associations to lupusSemantic proximity Read ↗

The SLE Transcriptome Exhibits Evidence of Chronic Endotoxin Exposure and Has Widespread Dysregulation of Non-Coding and Coding RNAsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.