Association of a common interferon regulatory factor 5 (IRF5) variant with increased risk of systemic lupus erythematosus (SLE).

doi:10.1111/j.1469-1809.2006.00336.x

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Article

Association of a common interferon regulatory factor 5 (IRF5) variant with increased risk of systemic lupus erythematosus (SLE).

Annals of human genetics - 1 May 2007

Demirci F Y K, Manzi S, Ramsey-Goldman R, Minster R L, Kenney M, Shaw P S, Dunlop-Thomas C M, Kao A H, Rhew E, Bontempo F, Kammerer C, Kamboh M I

Abstract excerpt

Interferon regulatory factor 5 (IRF5) belongs to a family of transcription factors that control the transactivation of type I interferon system-related genes, as well as the expression of several other genes involved in immune response, cell signalling, cell cycle control and apoptosis. Two recent studies reported a significant association between the IRF5/rs2004640 T allele and systemic lupus erythematosus...

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PMID: 17166181
DOI: 10.1111/j.1469-1809.2006.00336.x

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