Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus.

doi:10.1093/hmg/ddm359

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Article

Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus.

Human molecular genetics - 15 Mar 2008

Sigurdsson Snaevar, Göring Harald H H, Kristjansdottir Gudlaug, Milani Lili, Nordmark Gunnel, Sandling Johanna K, Eloranta Maija-Leena, Feng Di, Sangster-Guity Niquiche, Gunnarsson Iva, Svenungsson Elisabet, Sturfelt Gunnar, Jönsen Andreas, Truedsson Lennart, Barnes Betsy J, Alm Gunnar, Rönnblom Lars, Syvänen Ann-Christine

Abstract excerpt

We analyzed a comprehensive set of single-nucleotide polymorphisms (SNPs) and length polymorphisms in the interferon regulatory factor 5 (IRF5) gene for their association with the autoimmune disease systemic lupus erythematosus (SLE) in 485 Swedish patients and 563 controls. We found 16 SNPs and two length polymorphisms that display association with SLE (P < 0.0005, OR > 1.4). Using a Bayesian model selection and...

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PMID: 18063667
DOI: 10.1093/hmg/ddm359

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