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Article

Quantitating the frequency of initiation and cH-ras mutation in in situ N-methyl-N-nitrosourea-exposed rat mammary gland.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Jan 1991

Zhang R, Haag J D, Gould M N

Abstract excerpt

Mammary carcinogenesis is a multistep process consisting minimally of initiation and promotion/progression stages. The rate-limiting stage in the carcinogenesis process is undetermined but can in part be addressed by estimating the frequency of initiation, a heritable early event. Here, we use an in vivo limiting dilution transplantation assay to estimate initiation frequency in a rat mammary epithelial stem-like...

Topics

Animals
Base Sequence
Cell Survival
Female
Gene Expression Regulation, Neoplastic
Genes, ras
Mammary Neoplasms, Experimental
Methylnitrosourea
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats

Source

Identifiers

PMID: 2007094

Genes

NMU

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2007094-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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