Article
Carcinogen-induced mutations in the mouse c-Ha-ras gene provide evidence of multiple pathways for tumor progression.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jan 1990
Brown K, Buchmann A, Balmain A
Abstract excerpt
A number of mouse skin tumors initiated by the carcinogens N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), methylnitrosourea (MNU), 3-methylcholanthrene (MCA), and 7,12-dimethylbenz[a]anthracene (DMBA) have been shown to contain activated Ha-ras genes. In each case, the point mutations responsible for activation have been characterized. Results presented demonstrate the carcinogen-specific nature of these ras...
Topics
- 9,10-Dimethyl-1,2-benzanthracene
- Animals
- Base Sequence
- Carcinogens
- Codon
- DNA, Neoplasm
- Female
- Genes, ras
- Immunoblotting
- Methylcholanthrene
- Methylnitronitrosoguanidine