Ha-ras oncogene activation in mammary glands of N-methyl-N-nitrosourea-treated rats genetically resistant to mammary adenocarcinogenesis.

doi:10.1073/pnas.89.3.1001

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Article

Ha-ras oncogene activation in mammary glands of N-methyl-N-nitrosourea-treated rats genetically resistant to mammary adenocarcinogenesis.

Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 1992

Lu S J, Archer M C

Abstract excerpt

A single dose of N-methyl-N-nitrosourea given to sexually immature female Buf/N rats produces a high incidence of mammary adenocarcinomas. A large percentage of these tumors contain the Ha-ras oncogene, activated by a G----A transition at the second nucleotide of codon 12. Copenhagen rats, on the...

Topics

Animals
Base Sequence
Genes, ras
Mammary Glands, Animal
Mammary Neoplasms, Experimental
Methylnitrosourea
Molecular Sequence Data
Mutation
Oligodeoxyribonucleotides
Polymerase Chain Reaction
Proto-Oncogene Proteins p21(ras)
Rats

Source

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Identifiers

PMID: 1736280
DOI: 10.1073/pnas.89.3.1001
PMCID: PMC48373

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1736280-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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