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Article

Affinity with Raf is sufficient for Ras to efficiently induce rat mammary carcinomas.

Carcinogenesis - 1 Jan 2003

McFarlin Daniel R, Lindstrom Mary J, Gould Michael N

Abstract excerpt

The role of three major Ras downstream effector pathways in the induction of mammary cancer was studied using an in situ mammary ductal gene delivery model. Replication-defective retroviral vectors were used to infect endogenous rat mammary epithelial cells with three individual Ras effector loop mutants, each of which transduces its signal through a different Ras effector pathway (Raf, PI3K or RalGDS). Several...

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PMID: 12538354
DOI: 10.1093/carcin/24.1.99

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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