N-nitroso-N-methylurea-induced rat mammary tumors arise from cells with preexisting oncogenic Hras1 gene mutations.

doi:10.1073/pnas.91.9.3749

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Article

N-nitroso-N-methylurea-induced rat mammary tumors arise from cells with preexisting oncogenic Hras1 gene mutations.

Proceedings of the National Academy of Sciences of the United States of America - 26 Apr 1994

Cha R S, Thilly W G, Zarbl H

Abstract excerpt

GGA to GAA mutations in the 12th codon of the Hras gene are frequently observed in rat mammary tumors induced by N-nitroso-N-methylurea (NMU). We developed an assay to measure point mutations present in tissues at a frequency of 10(-5) and have now applied this assay to measure the specific G to...

Topics

Animals
Female
Genes, ras
Mammary Neoplasms, Experimental
Methylnitrosourea
Mutation
Oncogenes
Rats
Rats, Inbred F344

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