Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

N-nitroso-N-methylurea-induced rat mammary tumors arise from cells with preexisting oncogenic Hras1 gene mutations.

Proceedings of the National Academy of Sciences of the United States of America - 26 Apr 1994

Cha R S, Thilly W G, Zarbl H

Abstract excerpt

GGA to GAA mutations in the 12th codon of the Hras gene are frequently observed in rat mammary tumors induced by N-nitroso-N-methylurea (NMU). We developed an assay to measure point mutations present in tissues at a frequency of 10(-5) and have now applied this assay to measure the specific G to A transition of the Hras gene in rat mammary epithelium. We find that (i) 70% of untreated rats contain detectable...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to GAA gene
Share to Genes, ras
Share to Mammary Neoplasms, Experimental

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Methylnitrosourea

Share to Mutation

Share to Oncogenes

Share to Rats, Inbred F344

Source

Open in PubMed Open full text

Identifiers

PMID: 8170982
DOI: 10.1073/pnas.91.9.3749
PMCID: PMC43659

Genes

NMU
GAA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

N-nitroso-N-methylurea-induced rat mammary tumors arise from cells with preexisting oncogenic Hras1 gene mutations.PMID 8170982Read ↗

Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations.Semantic proximity Read ↗

Transgenic rats carrying human c-Ha-ras proto-oncogenes are highly susceptible to N-methyl-N-nitrosourea mammary carcinogenesis.Semantic proximity Read ↗

Absence of Ras mutations in rat DMBA-induced mammary tumors.Semantic proximity Read ↗

Mutational activation of c-Ha-ras genes in intraductal proliferation induced by N-nitroso-N-methylurea in rat mammary glands.Semantic proximity Read ↗

Ha-ras-1 oncogene mutations in mammary epithelial cells do not contribute to initiation of spontaneous mammary tumorigenesis in rats.Semantic proximity Read ↗

Specificity of mutations induced by N-methyl-N-nitrosourea in a cDNA of the hprt gene.Semantic proximity Read ↗

Transgenic rats carrying human c-Ha-ras proto-oncogene are highly susceptible to N-nitrosomethylbenzylamine induction of esophageal tumorigenesis.Semantic proximity Read ↗

Pathogenic characterization of 1-methyl-1-nitrosourea-induced mammary carcinomas in the rat.Semantic proximity Read ↗

Role of DNA repair in carcinogen-induced ras mutation.Semantic proximity Read ↗

Alterations in H-ras1 promoter conformation during N-nitroso-N-methylurea-induced mammary carcinogenesis and pregnancy.Semantic proximity Read ↗

Incidence of Harvey ras oncogene point mutations and their expression in methylbenzylnitrosamine-induced esophageal tumorigenesis.Semantic proximity Read ↗

Ha-ras oncogene activation in mammary glands of N-methyl-N-nitrosourea-treated rats genetically resistant to mammary adenocarcinogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.