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Article

Ha-ras-1 oncogene mutations in mammary epithelial cells do not contribute to initiation of spontaneous mammary tumorigenesis in rats.

Carcinogenesis - 1 Nov 1996

Cha R S, Guerra L, Thilly W G, Zarbl H

Abstract excerpt

We have previously shown that oncogenic GGA to GAA mutations in codon 12 of the Ha-ras-1 gene arise spontaneously during normal development of the mammary epithelium of female Fischer 344 (F344) rats. Our result further demonstrated that the vast majority of nitrosomethylurea (NMU)-induced rat mammary tumors with Ha-ras-1 oncogenes arose from these pre-existing mutants. We therefore investigated whether Ha-ras-1...

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Source

Identifiers

PMID: 8968072
DOI: 10.1093/carcin/17.11.2519

Genes

NMU
GAA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Ha-ras-1 oncogene mutations in mammary epithelial cells do not contribute to initiation of spontaneous mammary tumorigenesis in rats.PMID 8968072Read ↗

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ras gene mutations are absent in NMU-induced mammary carcinomas from aging rats.Semantic proximity Read ↗

Pathogenic characterization of 1-methyl-1-nitrosourea-induced mammary carcinomas in the rat.Semantic proximity Read ↗

Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations.Semantic proximity Read ↗

Ha-ras oncogene activation in mammary glands of N-methyl-N-nitrosourea-treated rats genetically resistant to mammary adenocarcinogenesis.Semantic proximity Read ↗

Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats.Semantic proximity Read ↗

N-nitroso-N-methylurea-induced rat mammary tumors arise from cells with preexisting oncogenic Hras1 gene mutations.Semantic proximity Read ↗

Quantitating the frequency of initiation and cH-ras mutation in in situ N-methyl-N-nitrosourea-exposed rat mammary gland.Semantic proximity Read ↗

Transgenic rats carrying human c-Ha-ras proto-oncogenes are highly susceptible to N-methyl-N-nitrosourea mammary carcinogenesis.Semantic proximity Read ↗

Activation of ras oncogenes preceding the onset of neoplasia.Semantic proximity Read ↗

Absence of p53 mutations in methylnitrosourea-induced mammary tumors in rats.Semantic proximity Read ↗

High susceptibility of transgenic rats carrying the human c-Ha-ras proto-oncogene to chemically-induced mammary carcinogenesis.Semantic proximity Read ↗

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