Ha-ras-1 oncogene mutations in mammary epithelial cells do not contribute to initiation of spontaneous mammary tumorigenesis in rats.

doi:10.1093/carcin/17.11.2519

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Article

Ha-ras-1 oncogene mutations in mammary epithelial cells do not contribute to initiation of spontaneous mammary tumorigenesis in rats.

Carcinogenesis - 1 Nov 1996

Cha R S, Guerra L, Thilly W G, Zarbl H

Abstract excerpt

We have previously shown that oncogenic GGA to GAA mutations in codon 12 of the Ha-ras-1 gene arise spontaneously during normal development of the mammary epithelium of female Fischer 344 (F344) rats. Our result further demonstrated that the vast majority of nitrosomethylurea (NMU)-induced rat ma...

Topics

Animals
Carcinogens
Cell Division
Codon
DNA Mutational Analysis
Epithelial Cells
Epithelium
Female
Genes, ras
Mammary Glands, Animal
Mammary Neoplasms, Experimental
Methylnitrosourea
Mutation
Rats
Rats, Inbred F344

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