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Article

Identification and quantification of a carcinogen-induced molecular initiation event in cell transformation.

Oncogene - 1 Nov 1992

Nakazawa H, Aguelon A M, Yamasaki H

Abstract excerpt

All transformed foci of Balb/c 3T3 clone A31-1-1 cells induced by 7,12-dimethylbenz[a]anthracene (DMBA) (42 out of 42 examined) contained an A to T transversion at codon 61 (A182 to T) of the Ki-ras gene. The transformants induced by other carcinogens tested did not contain such a mutation, except one out of nine 12-O-tetradecanoyl phorbol 13-acetate (TPA)-induced transformed foci. Thus, we hypothesized that this...

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PMID: 1437151

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