Article
Identification and quantification of a carcinogen-induced molecular initiation event in cell transformation.
Oncogene - 1 Nov 1992
Nakazawa H, Aguelon A M, Yamasaki H
Abstract excerpt
All transformed foci of Balb/c 3T3 clone A31-1-1 cells induced by 7,12-dimethylbenz[a]anthracene (DMBA) (42 out of 42 examined) contained an A to T transversion at codon 61 (A182 to T) of the Ki-ras gene. The transformants induced by other carcinogens tested did not contain such a mutation, except one out of nine 12-O-tetradecanoyl phorbol 13-acetate (TPA)-induced transformed foci. Thus, we hypothesized that this...
Topics
- 3T3 Cells
- 9,10-Dimethyl-1,2-benzanthracene
- Animals
- Base Sequence
- Carcinogens
- Cell Transformation, Neoplastic
- Gene Expression
- Genes, ras
- Mice
- Molecular Sequence Data
- Mutation