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Article

Mutational activation of c-Ha-ras genes in intraductal proliferation induced by N-nitroso-N-methylurea in rat mammary glands.

International journal of cancer - 19 Aug 1991

Sakai H, Ogawa K

Abstract excerpt

Although administration of a single dose of N-nitroso-N-methylurea (NMU) to young virgin rats induces a high rate of mammary carcinomas, precise histogenesis of the carcinomas has not been well characterized. In this study, we investigated the alterations of H-ras gene in early focal lesions as well as carcinomas in the mammary glands of F344 rats treated with NMU. At 2 weeks after treatment, intraductal...

Topics

Animals
Base Sequence
Cell Division
Genes, ras
Mammary Glands, Animal
Mammary Neoplasms, Experimental
Methylnitrosourea
Molecular Sequence Data
Mutation
Oligonucleotide Probes
Oligonucleotides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Rats

Rats, Inbred F344

Source

Identifiers

PMID: 1874567
DOI: 10.1002/ijc.2910490125

Genes

NMU

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1874567-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Mutational activation of c-Ha-ras genes in intraductal proliferation induced by N-nitroso-N-methylurea in rat mammary glands.PMID 1874567Read ↗

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