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Article

Mutational activation of c-Ha-ras genes in intraductal proliferation induced by N-nitroso-N-methylurea in rat mammary glands.

International journal of cancer - 19 Aug 1991

Sakai H, Ogawa K

Abstract excerpt

Although administration of a single dose of N-nitroso-N-methylurea (NMU) to young virgin rats induces a high rate of mammary carcinomas, precise histogenesis of the carcinomas has not been well characterized. In this study, we investigated the alterations of H-ras gene in early focal lesions as well as carcinomas in the mammary glands of F344 rats treated with NMU. At 2 weeks after treatment, intraductal...

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Source

Identifiers

PMID: 1874567
DOI: 10.1002/ijc.2910490125

Genes

NMU

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mutational activation of c-Ha-ras genes in intraductal proliferation induced by N-nitroso-N-methylurea in rat mammary glands.PMID 1874567Read ↗

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ras gene mutations are absent in NMU-induced mammary carcinomas from aging rats.Semantic proximity Read ↗

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