Activation of ras oncogenes preceding the onset of neoplasia.

doi:10.1126/science.2188364

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Activation of ras oncogenes preceding the onset of neoplasia.

Science (New York, N.Y.) - 1 Jun 1990

Kumar R, Sukumar S, Barbacid M

Abstract excerpt

The identification of ras oncogenes in human and animal cancers including precancerous lesions indicates that these genes participate in the early stages of neoplastic development. Yet, these observations do not define the timing of ras oncogene activation in the multistep process of carcinogenes...

Topics

Adenofibroma
Animals
Animals, Newborn
Base Sequence
Carcinoma
Cell Transformation, Neoplastic
Estrogens
Female
Gene Expression Regulation, Neoplastic
Genes, ras
Mammary Glands, Animal
Mammary Neoplasms, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Methylnitrosourea

Molecular Sequence Data

Mutation

Polymerase Chain Reaction

Rats

Rats, Inbred Strains

Source

Open in PubMed

Identifiers

PMID: 2188364
DOI: 10.1126/science.2188364

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2188364-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation of ras oncogenes preceding the onset of neoplasia.PMID 2188364Read ↗

ras oncogene detection in pre-neoplastic lesions: possible applications for diagnosis and prevention.Semantic proximity Read ↗

Activated N-ras oncogene and N-ras proto-oncogene act through the same pathway for in vivo tumorigenesis.Semantic proximity Read ↗

Reduction in the frequency of activated ras oncogenes in rat mammary carcinomas with increasing N-methyl-N-nitrosourea doses or increasing prolactin levels.Semantic proximity Read ↗

Role of proto-oncogene activation in carcinogenesis.Semantic proximity Read ↗

ras gene mutations are absent in NMU-induced mammary carcinomas from aging rats.Semantic proximity Read ↗

Proto-oncogene activation in rodent and human tumors.Semantic proximity Read ↗

Ha-ras-1 oncogene mutations in mammary epithelial cells do not contribute to initiation of spontaneous mammary tumorigenesis in rats.Semantic proximity Read ↗

Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats.Semantic proximity Read ↗

Mutational activation of c-Ha-ras genes in intraductal proliferation induced by N-nitroso-N-methylurea in rat mammary glands.Semantic proximity Read ↗

Hormone-induced protection of mammary tumorigenesis in genetically engineered mouse modelsSemantic proximity Read ↗

Transgenic rats carrying human c-Ha-ras proto-oncogene are highly susceptible to N-nitrosomethylbenzylamine induction of esophageal tumorigenesis.Semantic proximity Read ↗

Mammary gland neoplasia in long-term rodent studies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.