Article
Activation of H-ras oncogenes in preneoplastic mouse mammary tissues.
Oncogene - 1 Aug 1990
Kumar R, Medina D, Sukumar S
Abstract excerpt
The mammary hyperplastic outgrowth (HOG) line C4, resulted from serial transplantation of a hyperplastic alveolar nodule which arose in a dimethylbenz(a)anthracene (DMBA) treated mouse. The immortalized C4 outgrowth line, on transplantation into syngeneic mice, develops as preneoplastic, hyperplastic outgrowths and subsequently into malignant carcinomas after a long latent period (greater than 6 months)....
Topics
- 9,10-Dimethyl-1,2-benzanthracene
- Animals
- DNA, Neoplasm
- Female
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Mammary Neoplasms, Experimental
- Mice
- Mice, Inbred BALB C
- Mutation
- Polymerase Chain Reaction