Article
Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.
Annals of human genetics - 1 Mar 2010
Edwards Todd L, Scott William K, Almonte Cherylyn, Burt Amber, Powell Eric H, Beecham Gary W, Wang Liyong, Züchner Stephan, Konidari Ioanna, Wang Gaofeng, Singer Carlos, Nahab Fatta, Scott Burton, Stajich Jeffrey M, Pericak-Vance Margaret, Haines Jonathan, Vance Jeffery M, Martin Eden R
Abstract excerpt
Parkinson disease (PD) is a chronic neurodegenerative disorder with a cumulative prevalence of greater than one per thousand. To date three independent genome-wide association studies (GWAS) have investigated the genetic susceptibility to PD. These studies implicated several genes as PD risk loci with strong, but not genome-wide significant, associations. In this study, we combined data from two previously...
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