Article
SNCA Gene, but Not MAPT, Influences Onset Age of Parkinson's Disease in Chinese and Australians.
BioMed research international - 1 Jan 2015
Huang Yue, Wang Gang, Rowe Dominic, Wang Ying, Kwok John B J, Xiao Qin, Mastaglia Frank, Liu Jun, Chen Sheng-Di, Halliday Glenda
Abstract excerpt
BACKGROUND: α-Synuclein (SNCA) and microtubule-associated protein tau (MAPT) are the two major genes independently, but not jointly, associated with susceptibility for Parkinson's disease (PD). The SNCA gene has recently been identified as a major modifier of age of PD onset. Whether MAPT gene synergistically influences age of onset of PD is unknown. Objective. To investigate independent and joint effects of MAPT...
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