Article
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease.
Nature genetics - 1 Dec 2009
Satake Wataru, Nakabayashi Yuko, Mizuta Ikuko, Hirota Yushi, Ito Chiyomi, Kubo Michiaki, Kawaguchi Takahisa, Tsunoda Tatsuhiko, Watanabe Masahiko, Takeda Atsushi, Tomiyama Hiroyuki, Nakashima Kenji, Hasegawa Kazuko, Obata Fumiya, Yoshikawa Takeo, Kawakami Hideshi, Sakoda Saburo, Yamamoto Mitsutoshi, Hattori Nobutaka, Murata Miho, Nakamura Yusuke, Toda Tatsushi
Abstract excerpt
To identify susceptibility variants for Parkinson's disease (PD), we performed a genome-wide association study (GWAS) and two replication studies in a total of 2,011 cases and 18,381 controls from Japan. We identified a new susceptibility locus on 1q32 (P = 1.52 x 10(-12)) and designated this as PARK16, and we also identified BST1 on 4p15 as a second new risk locus (P = 3.94 x 10(-9)). We also detected strong...
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