Article

Shared Genetic Architecture Between Parkinson’s Disease and Sleep-Related Traits Implicates the<i>MAPT</i>Locus on Chromosome 17

2025-06-20

Abstract excerpt

<h4>ABSTRACT</h4> Parkinson’s disease (PD) is a neurodegenerative disorder characterised by both motor and non-motor symptoms. Among the latter, sleep disturbances are particularly common and include insomnia, obstructive sleep apnoea, excessive daytime sleepiness, restless legs syndrome, and REM sleep behaviour disorder. In this study, we investigated the shared genetic architecture between PD and sleep-related t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8d0343c3-1de6-5d5d-861d-caa30314b6aa
DOI: 10.1101/2025.06.19.25329954

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Shared Genetic Architecture Between Parkinson’s Disease and Sleep-Related Traits Implicates the<i>MAPT</i>Locus on Chromosome 17DOI 10.1101/2025.06.19.25329954Read

Genome-wide association study stratified by<i>MAPT</i>haplotypes identifies potential novel loci in Parkinson’s diseaseSemantic proximity Read

Full sequencing and haplotype analysis of MAPT in Parkinson's disease and rapid eye movement sleep behavior disorder.Semantic proximity Read

Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.Semantic proximity Read

Expanding Parkinson’s disease genetics: novel risk loci, genomic context, causal insights and heritable riskSemantic proximity Read

Genome-wide association study of REM-sleep behaviour disorder identifies new risk lociSemantic proximity Read

Genetics of cognitive dysfunction in Parkinson's disease.Semantic proximity Read

Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies.Semantic proximity Read

Family-based association analysis of the MAPT gene in Parkinson disease.Semantic proximity Read

Parkinson disease age of onset GWAS: defining heritability, genetic loci and a-synuclein mechanismsSemantic proximity Read

Genome-wide survival study identifies a novel synaptic locus and polygenic score for cognitive progression in Parkinson's disease.Semantic proximity Read

Shared and Sex-Specific Genetic Risk for Parkinson’s Disease Risk Across European PopulationsSemantic proximity Read

Genetic Architecture of MAPT Gene Region in Parkinson Disease SubtypesSemantic proximity Read