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Article

Genome-wide association study confirms extant PD risk loci among the Dutch.

European journal of human genetics : EJHG - 1 Jun 2011

Simón-Sánchez Javier, van Hilten Jacobus J, van de Warrenburg Bart, Post Bart, Berendse Henk W, Arepalli Sampath, Hernandez Dena G, de Bie Rob M A, Velseboer Daan, Scheffer Hans, Bloem Bas, van Dijk Karin D, Rivadeneira Fernando, Hofman Albert, Uitterlinden André G, Rizzu Patrizia, Bochdanovits Zoltan, Singleton Andrew B, Heutink Peter

Abstract excerpt

In view of the population-specific heterogeneity in reported genetic risk factors for Parkinson's disease (PD), we conducted a genome-wide association study (GWAS) in a large sample of PD cases and controls from the Netherlands. After quality control (QC), a total of 514,799 SNPs genotyped in 772 PD cases and 2024 controls were included in our analyses. Direct replication of SNPs within SNCA and BST1 confirmed...

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Identifiers

PMID: 21248740
DOI: 10.1038/ejhg.2010.254
PMCID: PMC3110043

Genes

SNCA
BST1
DGKQ
GAK
MAPT

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