Article
Genome-wide association study reveals genetic risk underlying Parkinson's disease.
Nature genetics - 1 Dec 2009
Simón-Sánchez Javier, Schulte Claudia, Bras Jose M, Sharma Manu, Gibbs J Raphael, Berg Daniela, Paisan-Ruiz Coro, Lichtner Peter, Scholz Sonja W, Hernandez Dena G, Krüger Rejko, Federoff Monica, Klein Christine, Goate Alison, Perlmutter Joel, Bonin Michael, Nalls Michael A, Illig Thomas, Gieger Christian, Houlden Henry, Steffens Michael, Okun Michael S, Racette Brad A, Cookson Mark R, Foote Kelly D, Fernandez Hubert H, Traynor Bryan J, Schreiber Stefan, Arepalli Sampath, Zonozi Ryan, Gwinn Katrina, van der Brug Marcel, Lopez Grisel, Chanock Stephen J, Schatzkin Arthur, Park Yikyung, Hollenbeck Albert, Gao Jianjun, Huang Xuemei, Wood Nick W, Lorenz Delia, Deuschl Günther, Chen Honglei, Riess Olaf, Hardy John A, Singleton Andrew B, Gasser Thomas
Abstract excerpt
We performed a genome-wide association study (GWAS) in 1,713 individuals of European ancestry with Parkinson's disease (PD) and 3,978 controls. After replication in 3,361 cases and 4,573 controls, we observed two strong association signals, one in the gene encoding alpha-synuclein (SNCA; rs2736990, OR = 1.23, P = 2.24 x 10(-16)) and another at the MAPT locus (rs393152, OR = 0.77, P = 1.95 x 10(-16)). We exchanged...
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