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Article

Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies.

Lancet (London, England) - 19 Feb 2011

Nalls Michael A, Plagnol Vincent, Hernandez Dena G, Sharma Manu, Sheerin Una-Marie, Saad Mohamad, Simón-Sánchez J, Schulte Claudia, Lesage Suzanne, Sveinbjörnsdóttir Sigurlaug, Stefánsson Kári, Martinez Maria, Hardy John, Heutink Peter, Brice Alexis, Gasser Thomas, Singleton Andrew B, Wood Nicholas W

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) for Parkinson's disease have linked two loci (MAPT and SNCA) to risk of Parkinson's disease. We aimed to identify novel risk loci for Parkinson's disease. METHODS: We did a meta-analysis of datasets from five Parkinson's disease GWAS from the USA and Europe to identify loci associated with Parkinson's disease (discovery phase). We then did replication analyses of...

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Source

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Identifiers

PMID: 21292315
DOI: 10.1016/S0140-6736(10)62345-8
PMCID: PMC3696507

Genes

MAPT
SNCA
ACMSD
BST1
CCDC62
GAK
LAMP3
MCCC1
STK39
SYT11

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