Independent and joint effects of the MAPT and SNCA genes in Parkinson disease.

doi:10.1002/ana.22321

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Article

Independent and joint effects of the MAPT and SNCA genes in Parkinson disease.

Annals of neurology - 1 May 2011

Elbaz Alexis, Ross Owen A, Ioannidis John P A, Soto-Ortolaza Alexandra I, Moisan Frédéric, Aasly Jan, Annesi Grazia, Bozi Maria, Brighina Laura, Chartier-Harlin Marie-Christine, Destée Alain, Ferrarese Carlo, Ferraris Alessandro, Gibson J Mark, Gispert Suzana, Hadjigeorgiou Georgios M, Jasinska-Myga Barbara, Klein Christine, Krüger Rejko, Lambert Jean-Charles, Lohmann Katja, van de Loo Simone, Loriot Marie-Anne, Lynch Timothy, Mellick George D, Mutez Eugénie, Nilsson Christer, Opala Grzegorz, Puschmann Andreas, Quattrone Aldo, Sharma Manu, Silburn Peter A, Stefanis Leonidas, Uitti Ryan J, Valente Enza Maria, Vilariño-Güell Carles, Wirdefeldt Karin, Wszolek Zbigniew K, Xiromerisiou Georgia, Maraganore Demetrius M, Farrer Matthew J

Abstract excerpt

OBJECTIVE: We studied the independent and joint effects of the genes encoding alpha-synuclein (SNCA) and microtubule-associated protein tau (MAPT) in Parkinson disease (PD) as part of a large meta-analysis of individual data from case-control studies participating in the Genetic Epidemiology of Parkinson's Disease (GEO-PD) consortium. METHODS: Participants of Caucasian ancestry were genotyped for a total of 4...

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Identifiers

PMID: 21391235
DOI: 10.1002/ana.22321
PMCID: PMC3082599

Genes

SNCA
MAPT

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