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Article

Chrna4 A529 knock-in mice exhibit altered nicotine sensitivity.

Pharmacogenetics and genomics - 1 Feb 2010

Wilking Jennifer A, Hesterberg Kirstin G, Crouch Eric L, Homanics Gregg E, Stitzel Jerry A

Abstract excerpt

The reasons why people smoke are varied, but research has shown that genetic influences on various aspects of nicotine addiction are a major factor. There also is a strong genetic influence on measures of nicotine sensitivity in mice. Despite the established contribution of genetics to nicotine sensitivity in mice and humans, no naturally occurring genetic variation has been identified that demonstrably alters...

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Share to Acetylcholine
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Share to Bridged Bicyclo Compounds, Heterocyclic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Nicotinic

Source

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Identifiers

PMID: 20061993
DOI: 10.1097/FPC.0b013e3283369347
PMCID: PMC2919848

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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