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Article

Functional Upregulation of α4* Nicotinic Acetylcholine Receptors in VTA GABAergic Neurons Increases Sensitivity to Nicotine Reward.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 3 Jun 2015

Ngolab Jennifer, Liu Liwang, Zhao-Shea Rubing, Gao Guangping, Gardner Paul D, Tapper Andrew R

Abstract excerpt

Chronic nicotine exposure increases sensitivity to nicotine reward during a withdrawal period, which may facilitate relapse in abstinent smokers, yet the molecular neuroadaptation(s) that contribute to this phenomenon are unknown. Interestingly, chronic nicotine use induces functional upregulation of nicotinic acetylcholine receptors (nAChRs) in the mesocorticolimbic reward pathway potentially linking...

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Identifiers

PMID: 26041923
DOI: 10.1523/JNEUROSCI.4453-14.2015
PMCID: PMC4588598

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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