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Article

Subtypes of nicotinic acetylcholine receptors in nicotine reward, dependence, and withdrawal: evidence from genetically modified mice.

Behavioural pharmacology - 1 Sept 2008

Fowler Christie D, Arends Michael A, Kenny Paul J

Abstract excerpt

Neuronal nicotinic acetylcholine receptors (nAChRs) can regulate the activity of many neurotransmitter pathways throughout the central nervous system and are considered to be important modulators of cognition and emotion. nAChRs are also the primary site of action in the brain for nicotine, the major addictive component of tobacco smoke. nAChRs consist of five membrane-spanning subunits (alpha and beta isoforms)...

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Identifiers

PMID: 18690103
DOI: 10.1097/FBP.0b013e32830c360e
PMCID: PMC2669417

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