Article
Nicotinic alpha7- or beta2-containing receptor knockout: effects on radial-arm maze learning and long-term nicotine consumption in mice.
Behavioural brain research - 23 Jan 2009
Levin Edward D, Petro Ann, Rezvani Amir H, Pollard Ninitia, Christopher N Channelle, Strauss Mariel, Avery Jessica, Nicholson Jessica, Rose Jed E
Abstract excerpt
Classically, it has been thought that high-affinity nicotinic receptors-containing beta2 subunits are the most important receptor subtypes for nicotinic involvement in cognitive function and nicotine self-administration, while low affinity alpha7-containing nicotinic receptors have not been thought to be important. In the current study, we found that knockout of either beta2 or alpha7 subunits caused significant...
Topics
- Animals
- Female
- Genotype
- Male
- Maze Learning
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Nicotine
- Nicotinic Agonists
- Psychomotor Performance
- Receptors, Nicotinic
- Self Administration