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Article

A polymorphism in the alpha4 nicotinic receptor gene (Chrna4) modulates enhancement of nicotinic receptor function by ethanol.

Alcoholism, clinical and experimental research - 1 May 2003

Butt Christopher M, Hutton Scott R, Stitzel Jerry A, Balogh Seth A, Owens Jeremy C, Collins Allan C

Abstract excerpt

BACKGROUND: Several studies indicate that ethanol enhances the activity of alpha4beta2 nicotinic acetylcholine receptors (nAChR). Our laboratory has identified a polymorphism in the alpha4 gene that results in the substitution of an alanine (A) for threonine (T) at amino acid position 529 in the second intracellular loop of the alpha4 protein. Mouse strains expressing the A variant have, in general, greater...

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PMID: 12766617
DOI: 10.1097/01.ALC.0000067973.41153.BC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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