Article
Genetic matters: thirty years of progress using mouse models in nicotinic research.
Biochemical pharmacology - 15 Oct 2013
Marks Michael J
Abstract excerpt
This research update summarizes thirty years of studies on genetic influences on responses to the acute or chronic administration of nicotine. Early studies established that various inbred mice are differentially sensitive to the effects of the drug. Classical genetic analyses confirmed that nicotine effects on locomotion, body temperature and seizures are heritable. A significant inverse correlation between the...
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