Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: converging evidence from human and animal research.

Abstract excerpt

Tobacco smoking is a leading preventable cause of death in the United States and produces a major health and economic burden. Although the majority of smokers want to quit, few are successful. These data highlight the need for additional research into the neurobiology of tobacco dependence. Addiction to nicotine, the main psychoactive component of tobacco, is influenced by multiple factors that include individual...

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