Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interaction between fibrinogen and IL-6 genetic variants and associations with cardiovascular disease risk in the Cardiovascular Health Study.

Annals of human genetics - 1 Jan 2010

Carty Cara L, Heagerty Patrick, Heckbert Susan R, Jarvik Gail P, Lange Leslie A, Cushman Mary, Tracy Russell P, Reiner Alexander P

Abstract excerpt

The inflammatory cytokine interleukin-6 (IL-6) is a main regulator of fibrinogen synthesis, though its interaction with fibrinogen genes (FGA, FGB, FGG) and subsequent impact on cardiovascular disease (CVD) risk is not well-studied. We investigated joint associations of fibrinogen and IL6 tagSNPs with fibrinogen concentrations, carotid intima-media thickness, and myocardial infarction or ischemic stroke in 3900...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiovascular Diseases
Share to Carotid Arteries

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fibrinogen

Share to Interleukin-6

Share to Models, Biological

Share to Myocardial Infarction

Share to Stroke

Source

Open in PubMed Open full text

Identifiers

PMID: 20059469
DOI: 10.1111/j.1469-1809.2009.00551.x
PMCID: PMC2946374

Genes

FGA
FGG
FGB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interaction between fibrinogen and IL-6 genetic variants and associations with cardiovascular disease risk in the Cardiovascular Health Study.PMID 20059469Read ↗

Fibrinogen and clot-related phenotypes determined by fibrinogen polymorphisms: Independent and IL-6-interactive associations.Semantic proximity Read ↗

Common genetic polymorphisms and haplotypes of fibrinogen alpha, beta, and gamma chains affect fibrinogen levels and the response to proinflammatory stimulation in myocardial infarction survivors: the AIRGENE study.Semantic proximity Read ↗

Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.Semantic proximity Read ↗

Epistatic and pleiotropic effects of polymorphisms in the fibrinogen and coagulation factor XIII genes on plasma fibrinogen concentration, fibrin gel structure and risk of myocardial infarction.Semantic proximity Read ↗

Association of genomic loci from a cardiovascular gene SNP array with fibrinogen levels in European Americans and African-Americans from six cohort studies: the Candidate Gene Association Resource (CARe).Semantic proximity Read ↗

Assessment of genetic determinants of the association of γ' fibrinogen in relation to cardiovascular disease.Semantic proximity Read ↗

Identification of gene-gene and gene-environment interactions within the fibrinogen gene cluster for fibrinogen levels in three ethnically diverse populations.Semantic proximity Read ↗

A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration.Semantic proximity Read ↗

Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts.Semantic proximity Read ↗

Polymorphism in the IL6 promoter region is associated with the risk factors and markers of subclinical atherosclerosis in men: The Cardiovascular Risk in Young Finns Study.Semantic proximity Read ↗

Variants in the coagulation factor 2 receptor (F2R) gene influence the risk of myocardial infarction in men through an interaction with interleukin 6 serum levels.Semantic proximity Read ↗

Proteogenomic integration reveals CXCL10 as a potentially downstream causal mediator for IL-6 signaling on atherosclerosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.