Article
Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.
Circulation. Cardiovascular genetics - 1 Apr 2009
Danik Jacqueline S, Paré Guillaume, Chasman Daniel I, Zee Robert Y L, Kwiatkowski David J, Parker Alex, Miletich Joseph P, Ridker Paul M
Abstract excerpt
BACKGROUND: Fibrinogen is a multifunctional circulating glycoprotein involved in wound healing, thrombosis, platelet aggregation, and inflammation, and elevated levels predict vascular disease. Despite evidence of crucial biological function and moderate heritability, comprehensive analysis of the influence of genetic variation on fibrinogen is not available. METHODS AND RESULTS: To address this issue, we...
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