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Proteogenomic integration reveals CXCL10 as a potentially downstream causal mediator for IL-6 signaling on atherosclerosis

2023-03-28

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Genetic and experimental studies support a causal involvement of interleukin-6 (IL-6) signaling in atheroprogression. While trials targeting IL-6 signaling are underway, any benefits must be balanced against an impaired host immune response. Dissecting the mechanisms that mediate the effects of IL-6 signaling on atherosclerosis could offer insights about novel drug targets wit...

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Literature Corpus work
e923074f-5c4c-51e7-aa31-d1cc15b37b7a
DOI
10.1101/2023.03.24.23287543
Open publication

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Proteogenomic integration reveals CXCL10 as a potentially downstream causal mediator for IL-6 signaling on atherosclerosisDOI 10.1101/2023.03.24.23287543
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