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Article

Fibrinogen and clot-related phenotypes determined by fibrinogen polymorphisms: Independent and IL-6-interactive associations.

PloS one - 1 Jan 2017

Cronjé H Toinét, Nienaber-Rousseau Cornelie, Zandberg Lizelle, de Lange Zelda, Green Fiona R, Pieters Marlien

Abstract excerpt

Interleukin-6 (IL-6) induces the expression of fibrinogen, and polymorphic variation within the fibrinogen genes is believed to alter the magnitude of this expression. The identification of the functional relevance of individual fibrinogen single nucleotide polymorphisms (SNPs) has been hindered by the high linkage disequilibrium (LD) reported in the European fibrinogen gene locus. This study investigated two...

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PMID: 29099861
DOI: 10.1371/journal.pone.0187712
PMCID: PMC5669433

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FGB

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