Article
Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts.
Circulation. Cardiovascular genetics - 1 Apr 2009
Dehghan Abbas, Yang Qiong, Peters Annette, Basu Saonli, Bis Joshua C, Rudnicka Alicja R, Kavousi Maryam, Chen Ming-Huei, Baumert Jens, Lowe Gordon D O, McKnight Barbara, Tang Weihong, de Maat Moniek, Larson Martin G, Eyhermendy Susana, McArdle Wendy L, Lumley Thomas, Pankow James S, Hofman Albert, Massaro Joseph M, Rivadeneira Fernando, Kolz Melanie, Taylor Kent D, van Duijn Cornelia M, Kathiresan Sekar, Illig Thomas, Aulchenko Yurii S, Volcik Kelly A, Johnson Andrew D, Uitterlinden Andre G, Tofler Geoffrey H, Gieger Christian, Psaty Bruce M, Couper David J, Boerwinkle Eric, Koenig Wolfgang, O'Donnell Christopher J, Witteman Jacqueline C, Strachan David P, Smith Nicholas L, Folsom Aaron R
Abstract excerpt
BACKGROUND: Fibrinogen is both central to blood coagulation and an acute-phase reactant. We aimed to identify common variants influencing circulation fibrinogen levels. METHODS AND RESULTS: We conducted a genome-wide association analysis on 6 population-based studies, the Rotterdam Study, the Framingham Heart Study, the Cardiovascular Health Study, the Atherosclerosis Risk in Communities Study, the Monitoring of...
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