Article
Common genetic polymorphisms and haplotypes of fibrinogen alpha, beta, and gamma chains affect fibrinogen levels and the response to proinflammatory stimulation in myocardial infarction survivors: the AIRGENE study.
Journal of the American College of Cardiology - 9 Sept 2008
Jacquemin Bénédicte, Antoniades Charalambos, Nyberg Fredrik, Plana Estel, Müller Martina, Greven Sonja, Salomaa Veikko, Sunyer Jordi, Bellander Tom, Chalamandaris Alexandros-Georgios, Pistelli Ricardo, Koenig Wolfgang, Peters Annette
Abstract excerpt
OBJECTIVES: This study was designed to investigate whether single nucleotide polymorphisms (SNPs) and haplotypes of the fibrinogen gene-cluster (fibrinogen chains alpha [FGA], beta [FGB], and gamma [FGG]) could explain the inter- and intraindividual variability of fibrinogen levels in patients with atherosclerosis. We also searched for genetic determinants affecting the responses of fibrinogen genes to...
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