Article
Epistatic and pleiotropic effects of polymorphisms in the fibrinogen and coagulation factor XIII genes on plasma fibrinogen concentration, fibrin gel structure and risk of myocardial infarction.
Thrombosis and haemostasis - 1 Mar 2006
Mannila Maria Nastase, Eriksson Per, Ericsson Carl-Göran, Hamsten Anders, Silveira Angela
Abstract excerpt
An intricate interplay between the genes encoding fibrinogen gamma (FGG), alpha (FGA) and beta (FGB), coagulation factor XIII (F13A1) and interleukin 6 (IL6) and environmental factors is likely to influence plasma fibrinogen concentration, fibrin clot structure and risk of myocardial infarction (MI). In the present study, the potential contribution of SNPs harboured in the fibrinogen, IL6 and F13A1 genes to these...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.