Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of PTP1B restores IRS1-mediated hepatic insulin signaling in IRS2-deficient mice.

Diabetes - 1 Mar 2010

González-Rodríguez Agueda, Mas Gutierrez Jose A, Sanz-González Silvia, Ros Manuel, Burks Deborah J, Valverde Angela M

Abstract excerpt

OBJECTIVE: Mice with complete deletion of insulin receptor substrate 2 (IRS2) develop hyperglycemia, impaired hepatic insulin signaling, and elevated gluconeogenesis, whereas mice deficient for protein tyrosine phosphatase (PTP)1B display an opposing hepatic phenotype characterized by increased sensitivity to insulin. To define the relationship between these two signaling pathways in the regulation of liver...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Forkhead Box Protein O1
Share to Glucosephosphate Dehydrogenase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin Receptor Substrate Proteins

Share to Insulin-Secreting Cells

Share to Phosphoenolpyruvate Carboxykinase (GTP)

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 1

Share to Resveratrol

Share to Stilbenes

Source

Open in PubMed Open full text

Identifiers

PMID: 20028942
DOI: 10.2337/db09-0796
PMCID: PMC2828646

Genes

IRS2
IRS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of PTP1B restores IRS1-mediated hepatic insulin signaling in IRS2-deficient mice.PMID 20028942Read ↗

Protein tyrosine phosphatase-1B in diabetes.Semantic proximity Read ↗

Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.Semantic proximity Read ↗

Disruption of insulin receptor substrate 2 (Irs2) causes non-obese type 2 diabetes with β-cell dysfunction in the golden (Syrian) hamsterSemantic proximity Read ↗

IRS2 takes center stage in the development of type 2 diabetes.Semantic proximity Read ↗

NOX4 Pathway as a Source of Selective Insulin Resistance and ResponsivenessSemantic proximity Read ↗

Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance.Semantic proximity Read ↗

Hepatic PTEN deficiency improves muscle insulin sensitivity and decreases adiposity in mice.Semantic proximity Read ↗

Reduced Circulating Insulin Enhances Insulin Sensitivity in Old Mice and Extends LifespanSemantic proximity Read ↗

Knockout Mice Challenge our Concepts of Glucose Homeostasis and the Pathogenesis of DiabetesSemantic proximity Read ↗

Reduced hepatic lipid content in Pten-haplodeficient mice because of enhanced AKT2/PKBβ activation in skeletal muscle.Semantic proximity Read ↗

Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice.Semantic proximity Read ↗

Cardiomyocyte-specific deletion of PTP1B protects against HFD-induced cardiomyopathy through direct regulation of cardiac metabolic signalingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.