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Article

Protein tyrosine phosphatase-1B in diabetes.

Biochemical pharmacology - 1 Oct 2000

Kennedy B P, Ramachandran C

Abstract excerpt

A role for protein tyrosine phosphatases in the negative regulation of insulin signaling and a putative involvement in the insulin resistance associated with type 2 diabetes have been postulated since their discovery. The recent demonstration that mice lacking the protein tyrosine phosphatase-1B (PTP-1B) have enhanced insulin sensitivity validates this. Furthermore, when fed a high fat diet, these mice maintained...

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Share to Diabetes Mellitus
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Tyrosine Phosphatase, Non-Receptor Type 1

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Source

Identifiers

PMID: 10974195
DOI: 10.1016/s0006-2952(00)00305-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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