Article

Disruption of insulin receptor substrate 2 (Irs2) causes non-obese type 2 diabetes with β-cell dysfunction in the golden (Syrian) hamster

2023-11-25

Abstract excerpt

<title>Abstract</title> <p>Because of the advent of genome-editing technology, gene knockout (KO) hamsters have become attractive research models for diverse diseases in humans. This study established a new KO model of diabetes by disrupting the insulin receptor substrate-2 (Irs2) gene in the golden (Syrian) hamster. Homozygous KO animals were born alive but delayed postnatal growth until adulthood. They showed h...

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Literature Corpus work: 2ba72697-8f93-5c87-8754-def0bdf80a6d
DOI: 10.21203/rs.3.rs-3602375/v1

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Disruption of insulin receptor substrate 2 (Irs2) causes non-obese type 2 diabetes with β-cell dysfunction in the golden (Syrian) hamsterDOI 10.21203/rs.3.rs-3602375/v1Read

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