Article
Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice.
Proceedings of the National Academy of Sciences of the United States of America - 18 Oct 2016
Zhang Zhao, Turer Emre, Li Xiaohong, Zhan Xiaoming, Choi Mihwa, Tang Miao, Press Amanda, Smith Steven R, Divoux Adeline, Moresco Eva Marie Y, Beutler Bruce
Abstract excerpt
We describe a metabolic disorder characterized by lipodystrophy, hepatic steatosis, insulin resistance, severe diabetes, and growth retardation observed in mice carrying N-ethyl-N-nitrosourea (ENU)-induced mutations. The disorder was ascribed to a mutation of kelch repeat and BTB (POZ) domain containing 2 (Kbtbd2) and was mimicked by a CRISPR/Cas9-targeted null allele of the same gene. Kbtbd2 encodes a BTB-Kelch...
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