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Article

NOX4 Pathway as a Source of Selective Insulin Resistance and Responsiveness

11 Feb 2012

Abstract excerpt

OBJECTIVE: Type 2 diabetes mellitus and related syndromes exhibit a deadly triad of dyslipoproteinemia, which leads to atherosclerosis; hyperglycemia, which causes microvascular disease; and hypertension. These features share a common, but unexplained, origin-namely, pathway-selective insulin resistance and responsiveness. Here, we undertook a comprehensive characterization of pathway-selective insulin resistance...

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PMID: 22328777
DOI: 10.1161/atvbaha.111.244525

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